Master Cell Bank
A Master Cell Bank (MCB) is like a secure savings account, but instead of money, it stores original, carefully preserved cells used in making biological medicines and products. Think of it as the 'gold standard' starting material that biotech companies use to ensure their products remain consistent over time. Just as a baker needs the same quality ingredients to make bread taste the same every time, pharmaceutical companies need these stored cells to make medicines consistently. These cells are kept in special ultra-cold freezers under strict conditions to ensure they stay exactly the same for years.
Examples in Resumes
Developed and maintained Master Cell Bank documentation for FDA compliance
Led team responsible for MCB preparation and testing
Established new Master Cell Bank protocols that improved product consistency
Typical job title: "Cell Culture Scientists"
Also try searching for:
Where to Find Cell Culture Scientists
Professional Organizations
Job Boards
Professional Networks
Example Interview Questions
Senior Level Questions
Q: How would you handle a contamination event in a Master Cell Bank?
Expected Answer: A senior candidate should explain the investigation process, containment procedures, documentation requirements, and steps to prevent future contamination. They should mention regulatory reporting requirements and backup procedures.
Q: What strategies would you implement to improve cell bank stability?
Expected Answer: Look for answers about storage conditions, monitoring systems, backup power, temperature tracking, and quality control processes. They should also mention staff training and emergency response procedures.
Mid Level Questions
Q: What documentation is required for Master Cell Bank creation?
Expected Answer: Should mention batch records, testing documentation, growth conditions, storage records, and contamination testing results. Understanding of GMP documentation requirements is important.
Q: Describe the typical testing performed on a Master Cell Bank.
Expected Answer: Should discuss sterility testing, cell viability checks, identity testing, and growth characteristics. Should understand why each test is important for quality control.
Junior Level Questions
Q: What are the basic storage requirements for a Master Cell Bank?
Expected Answer: Should know about proper freezer temperatures, monitoring systems, and basic handling procedures. Should understand the importance of maintaining specific storage conditions.
Q: Why is a Master Cell Bank important in biomanufacturing?
Expected Answer: Should explain that it ensures consistent starting material for production, maintains product quality, and meets regulatory requirements. Basic understanding of its role in manufacturing.
Experience Level Indicators
Junior (0-2 years)
- Basic cell culture techniques
- Laboratory documentation
- Aseptic technique
- Following SOPs
Mid (2-5 years)
- Cell bank maintenance
- Quality control testing
- GMP compliance
- Problem solving skills
Senior (5+ years)
- Process optimization
- Regulatory compliance
- Team management
- Risk assessment
Red Flags to Watch For
- Lack of aseptic technique knowledge
- Poor understanding of contamination control
- No experience with documentation systems
- Unfamiliarity with GMP requirements
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