Recruiter's Glossary

Examples: CRISPR • Single Cell Sequencing • Whole Genome Sequencing

Linkage Analysis

Term from Genetic Research industry explained for recruiters

Linkage Analysis is a method used by genetic researchers to find connections between genes and traits or diseases within families. Think of it like drawing a family tree but for specific genetic characteristics. Researchers use this approach to understand how certain traits or health conditions are passed down through generations. It's particularly useful when trying to identify which genes might be responsible for inherited diseases. This is one of several methods used in genetic research, alongside techniques like genome sequencing and association studies.

Examples in Resumes

Conducted Linkage Analysis studies on multi-generation families to identify disease-causing genes

Applied Linkage Analysis and Genetic Linkage methods to track inheritance patterns in rare disorders

Led research team in performing Linkage Analysis to map disease genes in family pedigrees

Typical job title: "Genetic Researchers"

Also try searching for:

Genetic Researcher Genetic Analyst Statistical Geneticist Bioinformatics Scientist Human Genetics Researcher Medical Geneticist Genomics Researcher

Where to Find Genetic Researchers

Professional Organizations

Online Communities

Job Resources

Example Interview Questions

Senior Level Questions

Q: How would you approach a complex family study where the disease pattern doesn't follow typical inheritance patterns?

Expected Answer: A senior researcher should discuss various analytical approaches, including considering factors like incomplete penetrance, variable expression, and the possibility of multiple genes being involved. They should mention how they would use different analysis tools and validate findings.

Q: Describe a challenging linkage analysis project you've led and how you overcame any obstacles.

Expected Answer: Look for answers that demonstrate project management skills, problem-solving abilities, and experience with handling complex family data. They should explain how they ensured data quality and managed team collaboration.

Mid Level Questions

Q: What methods do you use to verify the quality of family data before performing linkage analysis?

Expected Answer: Should explain basic data checking procedures, how to identify and handle missing data, and methods to verify family relationships and disease status information.

Q: How do you explain linkage analysis results to non-specialist colleagues or families?

Expected Answer: Should demonstrate ability to communicate complex genetic concepts in simple terms and explain the practical implications of findings.

Junior Level Questions

Q: What is a pedigree and why is it important in linkage analysis?

Expected Answer: Should be able to explain that a pedigree is a family tree showing inheritance patterns and describe how it's used to track genetic traits through generations.

Q: What basic statistical concepts are important in linkage analysis?

Expected Answer: Should demonstrate understanding of basic probability, inheritance patterns, and how genetic markers are used to track genes through families.