Recruiter's Glossary

Examples: Endotoxin Testing • GC-MS • Limit of Detection

Limit of Detection

Term from Laboratory Testing industry explained for recruiters

The Limit of Detection (LOD) is a basic concept in laboratory testing that tells us the smallest amount of something that can be reliably measured by a test method. Think of it like a microscope's ability to see tiny objects - there's always a point where things become too small to see clearly. In job contexts, this term shows up when candidates have experience determining how sensitive their testing methods are. It's particularly important in fields like environmental testing, pharmaceutical analysis, or food safety, where detecting very small amounts of substances matters.

Examples in Resumes

Improved Limit of Detection for trace metal analysis by optimizing testing procedures

Validated testing methods to achieve lower LOD for environmental contaminants

Developed new protocols that reduced Limit of Detection levels in water quality testing

Typical job title: "Laboratory Analysts"

Also try searching for:

Analytical Chemist Lab Technician Quality Control Analyst Research Scientist Method Development Scientist Laboratory Manager Quality Assurance Specialist

Where to Find Laboratory Analysts

Professional Organizations

Job Boards

Professional Networks

Example Interview Questions

Senior Level Questions

Q: How would you approach developing a new testing method with a lower limit of detection?

Expected Answer: A senior analyst should discuss step-by-step method development, including sample preparation optimization, instrument selection, validation procedures, and statistical analysis to prove the lower detection limit is reliable.

Q: How do you ensure your lab's LOD measurements remain consistent over time?

Expected Answer: Should explain quality control procedures, regular calibration checks, staff training, and documentation requirements to maintain consistent and reliable detection limits.

Mid Level Questions

Q: What factors can affect the limit of detection in your analyses?

Expected Answer: Should mention equipment condition, sample preparation quality, environmental factors like temperature, and operator technique as key factors affecting detection limits.

Q: How do you calculate and verify the limit of detection for a method?

Expected Answer: Should explain basic statistical approaches using blank samples and standards, and demonstrate understanding of replicate testing and validation procedures.

Junior Level Questions

Q: What is the difference between limit of detection and limit of quantitation?

Expected Answer: Should explain that LOD is the lowest detectable amount, while limit of quantitation is the lowest amount that can be reliably measured with accuracy.

Q: How do you handle samples that fall below the limit of detection?

Expected Answer: Should discuss proper reporting procedures, using terms like 'below LOD' or '< LOD', and understanding when to use different testing methods.