Interference Testing is a quality control process used in medical laboratories and diagnostic testing to ensure accurate test results. It helps identify if other substances in a patient's sample (like medications or foods) might affect the accuracy of test results. Think of it like checking if anything might 'interfere' with getting the right answer, similar to how background noise might interfere with hearing someone clearly. This type of testing is crucial for maintaining the reliability of medical tests and is required by regulatory bodies like the FDA and CAP (College of American Pathologists).
Developed protocols for Interference Testing in new blood analysis methods
Led Interference Studies for FDA submission of diagnostic products
Conducted Interference Analysis on new diagnostic platform, reducing false results by 30%
Typical job title: "Interference Testing Specialists"
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Q: How would you design an interference testing strategy for a new diagnostic test?
Expected Answer: Should discuss creating a comprehensive plan that includes common interfering substances, establishing acceptance criteria, and ensuring regulatory compliance. Should mention risk assessment and documentation requirements.
Q: How do you handle unexpected interference results?
Expected Answer: Should explain investigation process, root cause analysis, implementing corrective actions, and documentation procedures. Should mention communication with stakeholders and regulatory implications.
Q: What are common interferents you look for in diagnostic testing?
Expected Answer: Should list common substances like hemolysis, lipemia, icterus, and common medications. Should explain why these are important and how they affect results.
Q: How do you document interference testing results?
Expected Answer: Should describe proper documentation practices, including data collection, analysis methods, and report writing. Should mention quality system requirements.
Q: What is the purpose of interference testing?
Expected Answer: Should explain that it's to ensure test accuracy by identifying substances that might affect results. Should mention basic quality control concepts.
Q: What basic steps are involved in performing an interference test?
Expected Answer: Should describe sample preparation, control testing, and basic result interpretation. Should demonstrate understanding of laboratory safety practices.