Good Laboratory Practice (GLP) is a quality system for research laboratories that ensures consistency, reliability, and accuracy in testing and research. Think of it as a set of rules and procedures that make sure all lab work is done properly and can be trusted. It's especially important in places that test products for safety, like pharmaceutical companies, environmental testing labs, or food safety facilities. When someone mentions GLP on their resume, it means they understand and follow these important quality standards. This is similar to how restaurants follow food safety rules, but for scientific testing.
Managed laboratory operations following Good Laboratory Practice standards
Conducted safety studies in compliance with GLP regulations
Trained junior staff on Good Laboratory Practice protocols and documentation requirements
Typical job title: "Laboratory Technicians"
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Q: How would you set up a GLP compliance program in a new laboratory?
Expected Answer: A senior candidate should explain the process of establishing standard operating procedures (SOPs), training programs, documentation systems, and quality control measures. They should also mention the importance of regular audits and working with regulatory authorities.
Q: How do you handle a situation where you discover a deviation from GLP standards in historical data?
Expected Answer: They should discuss the importance of documenting the finding, investigating the root cause, assessing the impact on study results, implementing corrective actions, and communicating with relevant stakeholders and authorities if necessary.
Q: What documentation is required for GLP compliance?
Expected Answer: Should be able to explain the basics of lab notebooks, standard operating procedures, equipment logs, training records, and study reports. Should understand why proper documentation is important for regulatory compliance.
Q: How do you ensure the reliability of test equipment in a GLP environment?
Expected Answer: Should discuss calibration schedules, maintenance logs, verification procedures, and the importance of documenting any equipment issues or maintenance activities.
Q: What are the basic principles of Good Laboratory Practice?
Expected Answer: Should be able to explain basic concepts like proper documentation, following procedures, equipment maintenance, and the importance of accuracy and consistency in lab work.
Q: How do you maintain sample integrity in a GLP laboratory?
Expected Answer: Should describe proper sample handling, storage conditions, labeling requirements, and the importance of maintaining chain of custody documentation.