FISH

Term from Diagnostics industry explained for recruiters

FISH (Fluorescence In Situ Hybridization) is an important testing method used in medical laboratories to detect genetic changes in cells. Think of it as a special microscope technique that uses fluorescent markers to light up specific parts of genes or chromosomes, making them visible and countable. This helps doctors diagnose diseases, especially cancer, and choose the right treatments. It's like having a highlighter that marks specific words in a book, but in this case, it marks specific genetic information in cells.

Examples in Resumes

Performed FISH analysis on patient samples for cancer diagnosis

Conducted over 1,000 FISH tests annually with 99.9% accuracy rate

Supervised FISH laboratory operations and trained new technologists

Implemented new FISH protocols for improved diagnostic accuracy

Typical job title: "FISH Technologists"

Also try searching for:

Cytogenetic Technologist Molecular Technologist Clinical Laboratory Technologist Medical Laboratory Scientist Diagnostic Laboratory Technician FISH Analysis Specialist

Example Interview Questions

Senior Level Questions

Q: How would you handle quality control in a FISH laboratory?

Expected Answer: A senior technologist should discuss implementing quality control procedures, maintaining documentation, ensuring equipment calibration, and overseeing proficiency testing. They should mention experience with CAP and CLIA regulations.

Q: Describe how you would train new staff on FISH procedures.

Expected Answer: Should explain their approach to training, including hands-on demonstration, documentation review, competency assessment, and ongoing monitoring of new staff performance.

Mid Level Questions

Q: What steps do you take when FISH results are unclear?

Expected Answer: Should describe troubleshooting procedures, when to repeat tests, consultation with supervisors, and documentation requirements.

Q: How do you ensure accurate FISH signal counting?

Expected Answer: Should explain their method for systematic signal counting, use of controls, and verification procedures to ensure accuracy.

Junior Level Questions

Q: What safety precautions do you take when handling FISH specimens?

Expected Answer: Should discuss basic laboratory safety practices, proper handling of specimens, use of personal protective equipment, and waste disposal procedures.

Q: Describe the basic steps of a FISH procedure.

Expected Answer: Should be able to outline the main steps: sample preparation, slide preparation, probe application, washing, and visualization under the microscope.

Experience Level Indicators

Junior (0-2 years)

  • Basic FISH procedure execution
  • Laboratory safety practices
  • Simple specimen processing
  • Basic microscope operation

Mid (2-5 years)

  • Independent FISH analysis
  • Quality control procedures
  • Complex sample handling
  • Result interpretation

Senior (5+ years)

  • Laboratory management
  • Staff training and supervision
  • Protocol development
  • Regulatory compliance

Red Flags to Watch For

  • Unfamiliarity with basic laboratory safety procedures
  • Inability to describe quality control measures
  • Lack of attention to detail in documentation
  • No experience with microscope use
  • Poor understanding of contamination prevention