AAV
AAV (Adeno-Associated Virus) is a common tool used in genetic research and gene therapy. Think of it as a delivery vehicle that scientists use to transport genetic material into cells. It's similar to how a mail carrier delivers packages, but in this case, AAV delivers genes to specific cells in the body. Scientists often mention AAV in their work because it's considered very safe and efficient compared to other methods. When you see this term in resumes, it usually indicates experience with gene therapy research or genetic modification techniques.
Examples in Resumes
Developed protocols for AAV production and purification in gene therapy projects
Optimized AAV vector design for improved gene delivery efficiency
Led research team in AAV-based gene therapy experiments targeting rare diseases
Typical job title: "Gene Therapy Scientists"
Also try searching for:
Where to Find Gene Therapy Scientists
Professional Organizations
Job Boards
Research Networks
Example Interview Questions
Senior Level Questions
Q: How would you approach developing a new AAV-based gene therapy?
Expected Answer: Look for answers that show experience in planning complete gene therapy projects, including safety considerations, regulatory requirements, and ability to lead teams through the development process.
Q: What challenges have you faced with AAV production scale-up?
Expected Answer: The candidate should discuss practical experience with increasing production volumes while maintaining quality, troubleshooting common issues, and implementing solutions.
Mid Level Questions
Q: What methods do you use to test AAV purity and activity?
Expected Answer: Should be able to explain basic quality control procedures and common testing methods used to ensure AAV preparations are pure and effective.
Q: Describe your experience with different AAV serotypes.
Expected Answer: Should demonstrate knowledge of different AAV types and understanding of which ones work best for different applications.
Junior Level Questions
Q: What safety measures are important when working with AAV?
Expected Answer: Should show basic understanding of laboratory safety protocols and containment measures needed when handling viral vectors.
Q: Can you describe the basic steps of AAV production?
Expected Answer: Should be able to outline the fundamental steps in producing AAV, even if they haven't done all steps independently.
Experience Level Indicators
Junior (0-2 years)
- Basic cell culture techniques
- Understanding of AAV safety protocols
- Basic molecular biology techniques
- Laboratory documentation
Mid (2-5 years)
- AAV production and purification
- Vector design and modification
- Quality control testing
- Data analysis and documentation
Senior (5+ years)
- Project leadership
- Process optimization
- Regulatory compliance
- Technical team management
Red Flags to Watch For
- No hands-on laboratory experience
- Lack of understanding of basic safety protocols
- No experience with cell culture techniques
- Poor documentation practices
Related Terms
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