Recruiter's Glossary

Examples: Gene Annotation • PCR Techniques • Capillary Electrophoresis

Exome Sequencing

Term from Genetic Research industry explained for recruiters

Exome sequencing is a way to read and analyze important parts of our genes that contain instructions for making proteins in the body. Think of it like reading only the most important chapters of a book instead of the whole thing. Scientists use this method because it's faster and more cost-effective than analyzing all genetic material, while still providing valuable information about potential genetic conditions or diseases. It's similar to other genetic testing methods like whole genome sequencing or targeted gene panels, but focuses specifically on the protein-coding regions that are most likely to be involved in genetic disorders.

Examples in Resumes

Performed Exome Sequencing analysis for 200+ patient samples in cancer research studies

Led team of 3 technicians in Whole Exome Sequencing projects for rare disease identification

Optimized Exome Sequencing protocols reducing processing time by 30%

Typical job title: "Genetic Researchers"

Also try searching for:

Genomics Scientist Bioinformatics Scientist Clinical Molecular Geneticist Genetic Research Technologist NGS Scientist Molecular Biology Researcher

Where to Find Genetic Researchers

Professional Organizations

Online Communities

Job Boards

Example Interview Questions

Senior Level Questions

Q: How would you handle a large-scale exome sequencing project with multiple samples?

Expected Answer: Should discuss project management skills, quality control measures, data organization, and how to coordinate between lab work and data analysis. Should mention experience with handling multiple samples and maintaining sample tracking systems.

Q: What strategies would you use to identify clinically relevant variants in exome sequencing data?

Expected Answer: Should explain how they prioritize genetic variations, use of databases and tools for interpretation, and experience with clinical reporting. Should demonstrate understanding of medical implications.

Mid Level Questions

Q: What quality control measures do you use in exome sequencing?

Expected Answer: Should describe basic quality checks for DNA samples, sequencing data quality metrics, and how to identify and handle poor quality samples or data.

Q: How do you validate findings from exome sequencing?

Expected Answer: Should explain different validation methods, when to use alternative testing methods, and the importance of confirming results before clinical reporting.

Junior Level Questions

Q: Can you explain the basic workflow of exome sequencing?

Expected Answer: Should be able to describe the main steps from sample preparation to data generation, showing understanding of the basic laboratory procedures involved.

Q: What are the main differences between whole genome and exome sequencing?

Expected Answer: Should explain that exome sequencing focuses on protein-coding regions while whole genome covers all genetic material, and understand basic cost and time implications.