Sample Stability refers to how well medical or laboratory samples maintain their quality over time and under different storage conditions. This is crucial in medical testing, research, and diagnostics because unstable samples can lead to incorrect test results. When someone works with Sample Stability, they make sure that blood, urine, or other biological samples remain reliable from the time they're collected until they're tested. This involves understanding proper storage temperatures, handling procedures, and how long samples can be kept before testing. It's similar to making sure food stays fresh in your refrigerator, but for medical samples that need much more precise care.
Conducted Sample Stability studies for new diagnostic tests, extending viable testing windows by 24 hours
Led Sample Stability and Specimen Stability validation projects for 15 different diagnostic assays
Developed new Sample Stability protocols that improved storage conditions for sensitive biological materials
Typical job title: "Sample Stability Specialists"
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Q: How would you design a sample stability study for a new diagnostic test?
Expected Answer: A strong answer should explain the process of planning storage conditions, determining testing intervals, selecting appropriate sample types, and establishing acceptance criteria. They should mention the importance of regulatory compliance and documentation.
Q: What factors do you consider when establishing sample storage requirements?
Expected Answer: Should discuss temperature control, light exposure, container types, preservation methods, and how different sample types require different conditions. Should also mention cost considerations and practical implementation in a lab setting.
Q: How do you document and track sample stability studies?
Expected Answer: Should explain the importance of detailed record-keeping, tracking temperature logs, recording any deviations, and maintaining proper documentation for regulatory compliance. Should mention using laboratory information systems or tracking software.
Q: What do you do if you notice samples becoming unstable before the expected timeframe?
Expected Answer: Should discuss investigating root causes, implementing corrective actions, documenting findings, and communicating with team members and stakeholders about the issue and its resolution.
Q: What are the basic requirements for proper sample storage?
Expected Answer: Should be able to explain common storage temperatures (room temperature, refrigerated, frozen), proper labeling, and basic handling procedures to maintain sample integrity.
Q: How do you monitor sample storage conditions?
Expected Answer: Should describe basic monitoring procedures like checking and recording temperatures, ensuring proper storage unit function, and maintaining clean storage areas.