LC-MS
LC-MS (Liquid Chromatography-Mass Spectrometry) is a sophisticated laboratory testing method that scientists use to identify and measure different substances in samples. Think of it as a high-tech detective tool that can find tiny amounts of specific chemicals in complex mixtures. It combines two techniques: first, it separates the mixture into its parts (like sorting different colored marbles), then measures exactly what each part is and how much is present. This tool is widely used in drug testing, environmental analysis, food safety, and medical research. When you see this on a resume, it means the person has experience with advanced laboratory equipment and precise analytical methods.
Examples in Resumes
Performed sample analysis using LC-MS and LC/MS techniques for pharmaceutical quality control
Developed new testing methods using LC-MS for environmental contaminant detection
Managed LC-MS laboratory operations and trained junior analysts in LC/MS procedures
Typical job title: "LC-MS Analysts"
Also try searching for:
Where to Find LC-MS Analysts
Professional Organizations
Job Boards
Professional Networks
Example Interview Questions
Senior Level Questions
Q: How would you approach method development for a new compound that needs to be analyzed by LC-MS?
Expected Answer: A senior analyst should explain the step-by-step process of developing a new testing method, including sample preparation, choosing appropriate separation conditions, and validating the method to ensure accurate results.
Q: How do you handle instrument troubleshooting and maintenance?
Expected Answer: Should demonstrate knowledge of common problems, preventive maintenance schedules, and ability to diagnose and resolve technical issues to minimize downtime.
Mid Level Questions
Q: What quality control measures do you use when running LC-MS analysis?
Expected Answer: Should discuss using standard solutions, blanks, calibration curves, and system suitability tests to ensure reliable results.
Q: How do you prepare samples for LC-MS analysis?
Expected Answer: Should explain basic sample preparation techniques like filtration, dilution, and extraction, focusing on maintaining sample integrity.
Junior Level Questions
Q: What safety procedures do you follow when working with LC-MS instruments?
Expected Answer: Should mention basic laboratory safety practices, proper handling of chemicals, and awareness of emergency procedures.
Q: How do you document your analytical results?
Expected Answer: Should describe basic record-keeping practices, data organization, and following standard operating procedures for documentation.
Experience Level Indicators
Junior (0-2 years)
- Basic sample preparation
- Following standard operating procedures
- Data recording and documentation
- Basic instrument operation
Mid (2-5 years)
- Method implementation
- Quality control procedures
- Data analysis and interpretation
- Routine troubleshooting
Senior (5+ years)
- Method development and validation
- Complex problem solving
- Team training and supervision
- Project management
Red Flags to Watch For
- No hands-on experience with LC-MS instruments
- Lack of understanding of basic laboratory safety
- Poor documentation practices
- No experience with quality control procedures
Related Terms
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