Cross-reactivity
Cross-reactivity is an important concept in medical testing and diagnostics that describes when a test accidentally detects something similar to, but different from, what it's actually supposed to find. Think of it like a case of mistaken identity - when a test meant to detect one specific substance also picks up other similar substances. This is crucial in medical tests, especially in areas like allergy testing, drug screening, or disease diagnosis. Understanding cross-reactivity helps ensure test results are accurate and reliable.
Examples in Resumes
Developed new testing methods that reduced Cross-reactivity in COVID-19 antibody tests
Evaluated and documented Cross-reactivity patterns in allergy diagnostic panels
Led research team in minimizing Cross-reactivity issues in drug screening assays
Typical job title: "Diagnostic Specialists"
Also try searching for:
Where to Find Diagnostic Specialists
Professional Organizations
Job Boards
Online Networks
Example Interview Questions
Senior Level Questions
Q: How would you approach developing a new diagnostic test while minimizing cross-reactivity issues?
Expected Answer: Look for comprehensive answers about test design strategy, including target selection, validation protocols, and how they would identify and eliminate potential cross-reactive substances. They should mention quality control measures and regulatory requirements.
Q: Describe a time when you solved a complex cross-reactivity problem in a diagnostic test.
Expected Answer: Should describe a specific example showing leadership in problem-solving, including how they identified the issue, developed solutions, and implemented changes to improve test accuracy.
Mid Level Questions
Q: What methods do you use to evaluate cross-reactivity in diagnostic tests?
Expected Answer: Should be able to explain common testing methods, data analysis approaches, and how they document and report findings. Look for practical experience with validation protocols.
Q: How do you determine acceptable levels of cross-reactivity in a diagnostic test?
Expected Answer: Should discuss industry standards, regulatory requirements, and how test purpose affects acceptable cross-reactivity levels. Should mention risk assessment and clinical impact.
Junior Level Questions
Q: What is cross-reactivity and why is it important in diagnostic testing?
Expected Answer: Should provide a clear, basic explanation of cross-reactivity and its impact on test results. Should understand why it matters for test accuracy and patient care.
Q: What basic steps would you take to test for cross-reactivity?
Expected Answer: Should describe fundamental laboratory procedures for checking cross-reactivity, including basic control samples and documentation practices.
Experience Level Indicators
Junior (0-2 years)
- Basic laboratory techniques
- Understanding of test validation
- Data collection and documentation
- Following standard operating procedures
Mid (2-5 years)
- Test validation and optimization
- Cross-reactivity analysis
- Quality control procedures
- Method development support
Senior (5+ years)
- Advanced test development
- Regulatory compliance expertise
- Project leadership
- Troubleshooting complex cross-reactivity issues
Red Flags to Watch For
- Limited understanding of basic laboratory principles
- No experience with validation protocols
- Poor documentation practices
- Lack of knowledge about quality control measures
- Unfamiliarity with regulatory requirements
Related Terms
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