ADME stands for Absorption, Distribution, Metabolism, and Excretion. It describes how drugs move through and interact with the human body. Think of it as tracking a package from delivery to disposal - it shows how a medicine is absorbed into the body, spreads to where it needs to go, gets processed, and finally leaves the system. Understanding ADME is crucial for developing safe and effective medicines. This term is commonly used in drug development, clinical research, and pharmaceutical testing roles.
Conducted ADME studies for new drug candidates in preclinical development
Led team of scientists in ADME analysis for potential cancer treatments
Developed improved methods for ADME testing of pharmaceutical compounds
Typical job title: "ADME Scientists"
Also try searching for:
Q: How would you design an ADME strategy for a new drug candidate?
Expected Answer: A strong answer should discuss planning different types of tests to understand how the drug moves through the body, considering various factors like the type of drug, its intended use, and safety requirements. They should mention coordinating with different teams and understanding regulatory requirements.
Q: How do you handle unexpected results in ADME studies?
Expected Answer: Look for answers that show problem-solving skills, such as reviewing procedures, consulting with team members, running additional tests, and making informed decisions about whether to continue or modify the drug development process.
Q: What are the key factors that can affect drug absorption?
Expected Answer: Should explain in simple terms how things like food, age, other medications, and the way a drug is given can change how well the body absorbs it.
Q: How do you ensure the quality of ADME data?
Expected Answer: Should discuss following standard procedures, proper documentation, multiple testing, and quality control measures to make sure results are reliable and accurate.
Q: Can you explain what ADME stands for and why it's important?
Expected Answer: Should clearly explain that ADME means Absorption, Distribution, Metabolism, and Excretion, and why understanding these processes is crucial for drug development.
Q: What basic laboratory techniques are used in ADME studies?
Expected Answer: Should be able to describe common testing methods and basic lab procedures used to study how drugs move through and interact with the body.